The Learning Center For Men
Testosterone Levels Now Lower Than Ever
CONTEXT: Age-specific estimates of mean testosterone (T) concentrations appear to vary by year of observation and by birth cohort, and estimates of longitudinal declines in T typically outstrip cross-sectional decreases. These observations motivate a hypothesis of a population-level decrease in T over calendar time, independent of chronological aging…Continue Reading
Symptoms of Low Testosterone (Hypogonadism)
There is a high prevalence of hypogonadism in the older adult male population and the proportion of older men in the population is projected to rise in the future. As hypogonadism increases with age and is significantly associated with various comorbidities such as obesity, type 2 diabetes, hypertension, osteoporosis and metabolic syndrome, the physician is increasingly likely to have to treat hypogonadism in the clinic…Continue Reading
Low Testosterone and Mild Depression
OBJECTIVE: Hypogonadism and subthreshold depression are common conditions in elderly men. The objective of this study was to examine the effect of testosterone treatment in older, hypogonadal men with subthreshold depression…Continue Reading
Testosterone Replacement Improves Sexual Function
INTRODUCTION: Testosterone replacement therapy (TRT) has been shown to be beneficial for men with hypogonadism. However, it is unknown how well hypogonadal men respond to TRT based on the severity of testosterone deficiency…Continue Reading
Low Testosterone is a Cardiovascular Risk Factor
Male hypogonadism now has a new spectrum of complications. They are mainly cardiometabolic in nature. Low serum testosterone levels are a risk factor for diabetes, metabolic syndrome, inflammation and dyslipidemia…Continue Reading
Low Testosterone Increases Risk of Death
CONTEXT: Declining testosterone levels in elderly men are thought to underlie many of the symptoms and diseases of aging; however, studies demonstrating associations of low testosterone with clinical outcomes are few…Continue Reading
Men’s Testosterone Levels Decrease by About 1% Each Year
BACKGROUND: Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time…Continue Reading
Does Testosterone Cause Prostate Cancer?
It has been over 60 years since Huggins published his landmark work showing that castration caused regression of metastatic prostate cancer, linking forever the issues of prostate cancer and testosterone (T)…Continue Reading
Total Sleep Time Predicts Testosterone Levels in Older Men
STUDY OBJECTIVES: The circulating testosterone levels of healthy men decline with advancing age. This process is characterized by considerable inter-individual variability, the causes of which are of significant biological and clinical interest but remain poorly understood…Continue Reading
Sleep Restriction Reduces Testosterone Levels in Young Men
To the Editor: Chronic sleep curtailment is endemic in modern societies. The majority of the daily testosterone release in men occurs during sleep. 1 Sleep fragmentation and obstructive sleep apnea are associated with reduced testosterone levels…Continue Reading.
Clomiphene (Clomid) Increases Free Testosterone Levels in Men
Secondary hypogonadism is more common than primary gonadal failure and is seen in chronic and acute illnesses. Although testosterone has a role in erections, its importance in erectile dysfunction (ED) has been controversial. Hypogonadism produced by functional suppression of pituitary gonadotropins has been shown to correct with clomiphene citrate, but with a modest effect on sexual function…Continue Reading.
Clomiphene Citrate is Safe and Effective for Long-Term Treatment of Hypogonadism
Study Type - Therapy (population cohort) Level of Evidence 2a What’s known on the subject? and What does the study add? Clomiphene citrate(CC) has previously been documented to be efficacious in the treatment of hypogonadism. However little is known about the long term efficacy and safety of CC. Our study demonstrates that CC is efficacious after 3 years of therapy…Continue Reading.
Clomiphene Citrate and Testosterone Gel Replacement For Male Hypogonadism
INTRODUCTION: The efficacy of oral clomiphene citrate (CC) in the treatment ofmale hypogonadism and male infertility (MI) with low serumtestosterone and normal gonadotropin levels has been reported…Continue Reading.
Endogenous Testosterone and Mortality Due to all Causes, Cardiovascular Disease, and Cancer in Men
METHODS AND RESULTS: We examined the prospective relationship between endogenous testosterone concentrations and mortality due to all causes, cardiovascular disease, and cancer in a nested case-control study based on 11 606 men aged 40 to 79 years surveyed in 1993 to 1997 and followed up to 2003…Continue Reading.